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In addition, HMSeBA treatment significantly increased the expression of glutathione peroxidase 4 (GPX4) and SELS, while decreased ROS level and the expression of ER stress markers induced by hydrogen peroxide (H 2 O 2 ) in IPEC-J2 cells

Hansen et al

Foci formation of P53-binding protein 1 in thyroid tumors: activation of genomic instability during thyroid carcinogenesis

S., Leblanc, Mathieu, Wilson, David, Dutertre, Sebastien, King, Glenn F., Nicholson, Graham M

doi: 10.1073/pnas.89.6.2399 149 ZhangW.XiaoD.MaoQ.XiaH

Although it was originally developed to suppress oncogenic transcription factors such as androgen receptor and MYC, recent findings have shown that CCS1477 also effectively represses NRF2-dependent cytoprotective gene expression, which plays a central role in chemoresistance and immune evasion in KEAP1-mutant cancers [323]